Substances Authority for information on how to prevent and detect abuse or diversion of this product. Interactions with other CNS Depressants. Medscape – Detoxification, pain-specific dosing for Methadose, Dolophine opioids; Substantial interpatient variability, see prescribing information for guidance. Find patient medical information for Dolophine Oral on WebMD including its uses , side effects and safety, interactions, pictures, warnings and user ratings.

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Methadone tablets or oral solution should be reserved for patients in whom alternative treatment options e. Abrupt discontinuation of methadone in the methadone-maintained informatipn should be discouraged due to the potential for opioid withdrawal symptoms including lacrimation, rhinorrhea, sneezing, yawning, excessive perspiration, piloerection goose bumpsfever, chills, flushing, restlessness, irritability, weakness, anxiety, depression, dilated pupils, tremors, tachycardia, abdominal cramps, body aches, involuntary twitching ddolophine kicking movements, anorexia, nausea, vomiting, diarrhea, intestinal spasms, and weight loss.

Although breast-feeding may help mitigate withdrawal symptoms in the neonate, in some cases when methadone maintenance was used during pregnancy, the amount of methadone in breast milk may not be enough to fully avoid withdrawal in the infant.

When administered as an analgesic, methadone may be dispensed by any licensed pharmacy. Women who received methadone maintenance therapy for opioid dependence during pregnancy who are stable may be encouraged to breast-feed, unless another contraindication e. Intravenous, Subcutaneous, or Intramuscular dosage.

Methadone Dolophine, Methadose – Treatment – Hepatitis C Online

The total daily oral dose on Day 1 should not ordinarily exceed 40 mg. In ambulatory patients, a somewhat slower schedule may be required. Methadone is not recommended for analgesia during labor dolophinee obstetric delivery due to its long duration of action and potential for respiratory depression in the newborn. Administer dosage every 6 to 8 hours. Administer dosage every 8 to 12 hours.

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This will take roughly 1 minute. Patients receiving opioid dependance maintenance therapy with methadone are often under-treated or denied pain treatment. Opioid withdrawal symptoms have been associated with an increased risk of relapse to illicit drug use. This should be done in conjunction with an obstetrician who can monitor dolophhine effects on the fetus. Medical withdrawal of methadone maintenance is generally not recommended during pregnancy.

Patients with acute ulcerative colitis UC or other inflammatory bowel disease may be more sensitive to the constipating effects of opiate agonists. Dosage adjustments on subsequent days should be based on withdrawal symptom control at the time of expected prescrribing methadone activity 2 to 4 hours after dosing.

Accidental exposure, opioid-naive patients, potential for overdose or poisoning. Nevertheless, methadone should be used with caution in patients with biliary tract disease, including acute pancreatitis, or in patients undergoing biliary tract surgery.

Administration of methadone to pregnant animals during organogenesis through lactation resulted in decreased litter size, increased pup mortality, decreased pup body weights, developmental delays, and long-term neurochemical changes in the brain which correlate with altered behavioral responses at exposures comparable to and less than the human daily dose of mg.

Decreased respiratory drive and hypoventilation can cause carbon dioxide CO2 retention which can further increase intracranial pressure. Patients with CNS depression, head trauma, intracranial mass, brain tumor, or increased intracranial pressure should be given methadone with extreme caution. Advise breast-feeding women taking methadone to monitor the infant for increased drowsiness and breathing informtaion.


Neonates and infants younger than 6 months of age have highly variable clearance of opiate agonists.

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Divide the total daily methadone dose into an appropriate daily regimen. Respiratory depression, if left untreated, may cause respiratory arrest and death. A relapse to illicit drug use is prescrbing risk upon discontinuation.

Your Name Your name is required. For the treatment of narcotic addiction in detoxification programs, methadone may be dispensed only by pharmacies and clinics approved by the FDA and state authorities according to treatment requirements stipulated in the Federal Methadone Regulations.

If patients experience breakthrough pain, dose adjustment or a small rescue dose of an immediate-release analgesic should be considered. Asthma, chronic obstructive pulmonary disease COPDcoadministration with other CNS depressants, cor pulmonale, hypoxemia, obesity, pulmonary disease, respiratory depression, respiratory insufficiency, scoliosis, sleep apnea, status asthmaticus.

Pregnant women in methadone maintenance programs may have reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.

Seizures can be precipitated by opiate analgesics, particularly if used in high-doses and during opiate withdrawal. Monitor patients for symptoms of opioid-induced endocrinopathy.